Post-Op Monitoring: The 'Clean Slate' Protocol
DeepScan Marketing12/8/2025

Post-Op Monitoring: The 'Clean Slate' Protocol

Did the surgery get it all? How to use the rapid clearance of cfDNA to check for residual disease 14 days after tumor removal.

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IMHA, NETs, and the Clotting Risk: The DNA Connection
DeepScan Marketing12/1/2025

IMHA, NETs, and the Clotting Risk: The DNA Connection

Immune-Mediated Hemolytic Anemia is a thrombotic disease. We explain how 'DNA webs' (NETs) released by neutrophils fuel the fire and trigger clots.

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Trauma and Ischemia: Quantifying the 'Hit'
DeepScan Marketing11/24/2025

Trauma and Ischemia: Quantifying the 'Hit'

From hit-by-cars to GDVs, necrosis releases massive amounts of DNA. How cfDNA correlates with the 'Injury Severity Score' and helps triage the multi-trauma patient.

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The 'Cooler' Fallacy: Why You Can't Mail EDTA Tubes on the Weekend
DeepScan Marketing11/17/2025

The 'Cooler' Fallacy: Why You Can't Mail EDTA Tubes on the Weekend

Putting a blood tube in a styrofoam box with an ice pack is not 'preservation.' It is a recipe for lysis. We explain the thermodynamics of shipping failure.

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Sepsis vs. SIRS: Can DNA Tell the Difference?
DeepScan Marketing11/10/2025

Sepsis vs. SIRS: Can DNA Tell the Difference?

Inflammation looks a lot like infection on a blood panel. We explore why cfDNA rises in both, and how it helps quantify the 'cytokine storm'.

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Myths and Misconceptions: What cfDNA Cannot Do
DeepScan Marketing11/3/2025

Myths and Misconceptions: What cfDNA Cannot Do

A negative test doesn't guarantee health, and a positive test doesn't always mean cancer. We debunk the binary thinking that leads to clinical errors.

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Beyond Cancer: cfDNA as a 'Severity Meter' in the ICU
DeepScan Marketing10/27/2025

Beyond Cancer: cfDNA as a 'Severity Meter' in the ICU

In the Emergency Room, we aren't looking for mutations. We are looking for the total burden of cell death. How to use cfDNA to quantify exactly how hard the patient has been hit.

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When to Say No: Sample Rejection Criteria for the General Practitioner
DeepScan Marketing10/12/2025

When to Say No: Sample Rejection Criteria for the General Practitioner

It hurts to throw away a sample, but running a compromised test is worse. A checklist of 4 deal-breakers that mean you must redraw.

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Tissue of Origin: The Holy Grail of Veterinary Liquid Biopsy
DeepScan Marketing10/5/2025

Tissue of Origin: The Holy Grail of Veterinary Liquid Biopsy

We can find cancer in the blood, but can we tell you where it is? We explore the current limits of localization and the future promise of methylation panels.

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Lipemia: The Optical Illusion That Breaks Assays
DeepScan Marketing9/28/2025

Lipemia: The Optical Illusion That Breaks Assays

Fat in the blood doesn't just look bad; it scatters light and clogs filters. How lipemia distorts cfDNA values and how to handle the 'milky' sample.

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Freeze-Thaw Cycles: How to Shatter a Molecule
DeepScan Marketing9/21/2025

Freeze-Thaw Cycles: How to Shatter a Molecule

Ice crystals are sharp. We explain why refreezing a plasma sample shears long DNA fragments and ruins 'integrity index' diagnostics.

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The 4-Hour Rule: The Biology Behind the Clock
DeepScan Marketing9/14/2025

The 4-Hour Rule: The Biology Behind the Clock

Why do samples degrade after 4 hours? It's not just 'aging'—it's a biological cascade of glucose depletion and white blood cell suicide.

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Nucleosomes vs. cfDNA: Same Biological Event, Different Diagnostic Signal
DeepScan Marketing9/7/2025

Nucleosomes vs. cfDNA: Same Biological Event, Different Diagnostic Signal

DNA doesn't float naked in the blood—it is wrapped around histone spools called nucleosomes. We explain why measuring the 'spool' might sometimes be better than measuring the 'thread'.

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Hemolysis: The 'Red' Flag That Ruins Results
DeepScan Marketing8/31/2025

Hemolysis: The 'Red' Flag That Ruins Results

Why pink plasma leads to false negatives, and how to define rejection criteria for hemolyzed samples.

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cfDNA vs. ctDNA: Finding the Intruder in the House
DeepScan Marketing8/24/2025

cfDNA vs. ctDNA: Finding the Intruder in the House

Why 'high DNA' doesn't always mean cancer, and how sensitive assays separate the tumor signal (ctDNA) from the background noise (cfDNA).

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Logistics: Shipping cfDNA Without Ruining the Sample
DeepScan Marketing8/17/2025

Logistics: Shipping cfDNA Without Ruining the Sample

From dry ice disasters to room-temperature rules: a guide to the physics of sample stability during transit.

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Plasma vs. Serum: Why the Red Top Tube is Forbidden
DeepScan Marketing8/10/2025

Plasma vs. Serum: Why the Red Top Tube is Forbidden

Using serum for cfDNA testing is the most common rookie mistake. We explain why the clotting process creates a 'genomic explosion' that invalidates results.

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The Double-Spin Protocol: Why One Centrifuge Run is Not Enough
DeepScan Marketing8/3/2025

The Double-Spin Protocol: Why One Centrifuge Run is Not Enough

Standard clinic centrifuge protocols leave platelets and debris behind. Learn why the 'Double-Spin' is the mandatory standard for liquid biopsy.

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Apoptosis, Necrosis, and NETosis: The Three Engines of Cell-Free DNA
DeepScan Marketing7/27/2025

Apoptosis, Necrosis, and NETosis: The Three Engines of Cell-Free DNA

Not all DNA in the blood is the same. We break down the three biological mechanisms that release DNA—programmed death, traumatic injury, and immune defense—and what they tell us about a patient's disease.

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Fragmentomics: Why Size Matters in Cancer Detection
DeepScan Marketing7/20/2025

Fragmentomics: Why Size Matters in Cancer Detection

It’s not just how much DNA is in the blood, but how long the pieces are. Learn how 'fragmentomics' allows us to spot cancer even when total DNA levels are normal.

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The Tube Wars: K3-EDTA vs. Cell Stabilization Tubes
DeepScan Marketing7/13/2025

The Tube Wars: K3-EDTA vs. Cell Stabilization Tubes

Why does a $0.50 tube ruin a $300 test? We break down the chemistry of EDTA vs. Streck tubes and help you decide which one your clinic needs.

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The Speed of Signal: Why cfDNA Half-Life Changes Everything
DeepScan Marketing7/6/2025

The Speed of Signal: Why cfDNA Half-Life Changes Everything

Unlike antibodies that linger for months, cfDNA is a 'real-time' biomarker that clears in minutes. Here is how to use that speed for post-surgical monitoring and trauma triage.

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Defining 'Normal': Reference Intervals and Biological Variation in Dogs
DeepScan Marketing6/29/2025

Defining 'Normal': Reference Intervals and Biological Variation in Dogs

How much cfDNA is too much? We review the data on healthy baselines, the impact of age and breed, and why '0.0' is not the goal.

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The Golden Rules: A Clinic SOP for Preanalytical cfDNA Handling
DeepScan Marketing6/22/2025

The Golden Rules: A Clinic SOP for Preanalytical cfDNA Handling

A missed 10-minute window or a single freeze-thaw cycle can ruin a liquid biopsy. Here is the strict Standard Operating Procedure (SOP) every clinic needs.

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cfDNA 101: The Biology of the 'Liquid Biopsy' in Veterinary Medicine
DeepScan Marketing6/15/2025

cfDNA 101: The Biology of the 'Liquid Biopsy' in Veterinary Medicine

A deep dive into the origins of cell-free DNA—apoptosis, necrosis, and NETosis—and why this 'real-time' biomarker is revolutionizing veterinary diagnostics.

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